SECTION: PHARMACEUTICAL ANALYSIS/QUALITY ASSURANCE/REGULATORY AFFAIRS

Simultaneous HPLC determination of Metronidazole, Lidocaine and Miconazole in a combined intravaginal semi solid dosage form
Tanja Bakovska Stoimenova1*, Marjan Piponski1, Irena Slaveska Spirevska1, Kristina Grncharoska1, Marika Bogoevska Nikolovska1, Kristina Varsamovska1, Maksim Osman Nikolov1
REPLEK FARM LTD Skopje, Kozle 188, 1000 Skopje, Republic of North Macedonia

Development and validation of a RP-HPLC method for simultaneous determination of benzydamine hydrochloride and cetylpiridinium chloride in oral spray solution
Marjan Piponski*1, Irena Slaveska Spirevska1, Tanja Bakovska Stoimenova1, Milena Prculovska1, Marijana Nikoloska1, Angela Nikolovska1, Liliya Logoyda2
1Replek Farm Ltd., Kozle 188, 1000 Skopje, N. Macedonia
2Department of Pharmaceutical Chemistry, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

Understanding and evaluation of different degradation pathways and stability of drug product with active substance prone to chemical and physical degradation
Ana Atanasova1*, Frosina Jovanovikj1, Isidora Miovska1, Veronika Popovska Jakimovska1, Maja Stevanoska1, Filip Gogu1, Packa Antovska1, Jelena Lazova1, Nikola Geskovski2, Jasmina Tonic Ribarska2
1Research and development, Alkaloid AD Skopje, Aleksandar Makedonski 12, 1000, Skopje, Republic of North Macedonia
2Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje, Majka Tereza 47, 1000 Skopje, Skopje, Republic of North Macedonia

ANNEX 21 Importation of medicinal products
Ksenija Brzilova1, Vanja Bobevska1, Jasmina Kimovska1, Verče Jovanovska Jankovska1, Elizabeta Karadžinska2, Nada Popstefanova2, Olivera Paneva2, Stefan Petrovski2, Maja Velinovska Cadinovska2, Sanja Uskokova2
1ALKALOID AD Skopje, Blvd. Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia
2ALKALOID AD Skopje, Blvd. Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Batch certification document Certificate of Analysis / Certificate of Compliance
Sanja Uskokova1, Verče Jovanovska Jankovska1, Jasmina Kimovska1, Vanja Bobevska1, Elizabeta Karadžinska2, Nada Popstefanova2, Olivera Paneva2, Stefan Petrovski2, Ksenija Brzilova2, Maja Velinovska Cadinovska2
1ALKALOID AD Skopje, Blvd. Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Challenges in the development and registration of generic topical products
Belma Asanova*, Emilija Davidova*, Natasha Vukikjevikj
Alkaloid AD Skopje, Blvd. Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Application of experimental design for determination of insulin analogs
Blerta Pajaziti1, Melinda Andrási2, Liljana Anastasova1, Dashnor Nebija3, Blin Pajaziti3, Rumenka Petkovska1*
1Faculty of Pharmacy, Ss. Cyril and Methodius University, Mother Theresa 47, 1000 Skopje, North Macedonia,
2Department of Inorganic and Analytical Chemistry, University of Debrecen, Egyetem tér. 1, 4032 Debrecen, Hungary
3Department of Pharmacy, University of Prishtina “Hasan Prishtina, Bulevardi i Dëshmorëve, p.n., 10000 Prishtina, Kosovo

Challenges of possible replacement of titanium dioxide in Dapoxetine film coated tablets
Ana Smileva, Natalija Dimovska, Biljana Keleshovska, Dobrinka Dimova, Liljana Makraduli
Replek Farm Ltd., Kozle 188, 1000, Skopje, N. Macedonia

Cleaning validation concept for introduction of product with new active pharmaceutical ingredient in pharmaceutical production
Elisaveta Adamova Abrasheva*, Darko Atanasoski, Natasha Kronevska, Ana Ivcheska, Elizabeta Karadzinska, Olivera Paneva
ALKALOID AD Skopje, Pharmaceutical, Chemical and Cosmetics Company, Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Continuous process verification on blister packaging
Biljana Petrovska Jakimovska*, Dance Dukoska*, Irena Zdraveska, Maja Lazarova, Milkica Gligorova
AD Alkaloid, bul. Aleksandar Makedonski br.12, 1000 Skopje, North Macedonia

Creating and management of stability studies in AlkaSAP system
Marina Mandzukovska Micevska*, Dragana Kafedziska, Milena Nanov, Mena Ivanoska Zdravkovska, Petranka Petruseva Janoska, Vasilka Dubrova Koceva
Alkaloid AD Skopje, Blvd. Aleksandar Makedonski 12, 1000 Skopje, Republic of Macedonia

Development and validation of an HPLC method for determination of Heparin in Alven® gel
Marija Gjorgjieva*, Marija Kostova, Magdalena Atanasovski, Gordana Mitrovska Evgenievska, Maja Gjorgjeska, Hristina Babunovska
Alkaloid AD, Pharmaceutical, Chemical and Cosmetics Company, Blvd.  Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Development and Validation of HPLC method for determination of Methylprednisolone aceponate in cream
Paulina Apostolova1, Dino Karpicarov1*, Marija Arev1, Emilija Janevik-Ivanovska1, Biljana Gjorgjeska1, Zorica Arsova-Sarafinovska1,2.
1Department of Pharmacy, Faculty of Medical Sciences, Goce Delchev University of Shtip, Krste Misirkov No. 10-A, 2000 Shtip, Republic of North Macoedinia
2Institute of Public Health of Republic of North Macedonia, 50-ta Divizija 6, 1000 Skopje, Republic of North Macedonia

Development, optimization and validation of GC-FID method for determination of levomenthol in topical (gel) formulation
Olivera Blažeska, Elena Kazandzievska, Packa Antovska, Natasa Anevska-Sojanovska, Jelena Lazova
Research & Development, ALKALOID AD, Blv. Aleksandar Makedonski 12, 1000 Skopje, R. S. Macedonia

A scoping review of regulatory guidelines for the assurance of medicinal product quality throughout their lifecycle
Ermira Krasniqi1,2*, Jelena Ascevska1, Katerina Brezovska1, Arben Boshnjaku3, Aneta Dimitrovska1
1 Faculty of Pharmacy, Ss Cyril and Methodius University in Skopje, Majka Tereza 47, 1000 Skopje, R.N. Macedonia
2Faculty of Pharmacy, Alma Mater Europaea Campus “Rezonanca”, Glloku te Shelgjet ” Veternik”, 10000 Prishtinë, Kosova
3Faculty of Medicine, University ”Fehmi Agani” in Gjakova, 50000 Gjakovë, Kosova

Assessing imatinib mesylate in two different solid dosage forms
Ela Hoti1*, Leonard Deda2, Viola Gjylameti1
1Department of Pharmacy, Faculty of Medicine, UMT, Tirana, Albania.
2Applied Pharmacokinetics Lab, Dep. of Biomedical Sciences, Faculty of Medicine, UMT, Tirana, Albania

Implementation of the IDMP standards in the European Union
Filip Cvetanovski*, Aleksandar Jovanov, Despina Spasevska-Kovacki, Natasa Jovanovska
Alkaloid AD Skopje, blvd. Aleksandar Makedonski 12, 1000 Skopje, Republic of N. Macedonia

Implementation of EU legislation on counterfeit/falsified medicines: aspects of the pharmaceutical industry
Blagica Samarova Stoev*, Dafinka Damcevska, Mena I. Zdravkovska, Silvija Saveska, Tatjana Bogovska, Nada Stojanoska
Alkaloid AD Skopje, Blvd. Aleksandar Makedonski 12, 1000 Skopje, Republic of Macedonia

Improvement of the analytical method for content determination of Rosuvastatin film coated tablets during lifecycle
Aleksandra Damjanoska*, Cveta Dolikjoska Trajkova, Matilda Petrova, Milena Nikolovska, Mena Ivanoska Zdravkovska, Hristina Babunovska
Alkaloid AD Skopje, Blvd. Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia 

Influence of quality control on the process of drying herbal plants
Dajana Gligorić*1, Biljana Vasić 2, Dragana Đuričić3
1Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11140 Belgrade, Republic of Serbia
2Pharmaceutical University, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Republic of Serbia
3Megatrend University, Bulevar marsala Tolbuhina 8, 11070 Belgrade, Republic of Serbia

Introduction of new premises, equipment and process of raw materials grinding in production of oral solid dosage forms
Ana Ivcheska*, Marija Runcheva*, Natasha Kronevska, Darko Atanasoski, Elisaveta Adamova Abrasheva, Meri Davcheva, Elizabeta Karadzinska
ALKALOID AD Skopje, Pharmaceutical, Chemical and Cosmetics Company, Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Investigation of the effect of different flow-through cell design on the release of prolonged release tablets
Magdalena Velichkovska*, Filip Smilchevski, Ema Ilievska Vidanovska, Maja Hadzieva Gigovska, Blagica Manchevska, Sonja Dimchevska, Packa Antovska, Sonja Ugarkovic
Alkaloid AD, Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Validation of analytical method for determination of bioburden for citeral 3mg/mL eye and ear drops, 5mL
Ivanco Sinadinoski*, Silvana Ilioska Zlatanovic, Adriana Nosacheva Trajkovska, Maja Daskalova Simjanovska, Hristina Babunovska
Alkaloid AD Skopje, Blvd.Aleksandar Makedonski 12, 1000 Skopje, North Macedonia

Electronic product information (ePI): Expanded access to information on medicines in the European Union (EU)
Izabela Stojchevska*, Natasha Vukikjevikj
Alkaloid AD Skopje, blvd. Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Thermal-cycling stress studies to support transport and distribution of liquid dosage forms
Katerina Veljanovska*, Dusica Angelovska, Angelovska, Gabriela Pehcheska3Pehcheska
Alkaloid AD, Research and Development, Boulevard Aleksandar Makedonski 12, 1000 Skopje, Macedonia

Legislation of medical devices and Covid-19
Irina Gjureska1*, Natasha Vukikjevikj1, Suzana Trajkovic Jolevska2, Jasmina Tonic Ribarska2
1Alkaloid AD Skopje, Blvd. Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia
2Faculty of Pharmacy, UKIM, Mother Teresa Str., 47, 1000 Skopje, Republic of North Macedonia

Determination of Loratadine residues from surfaces of manufacturing equipment and settings acceptance limits for cleaning validation
Katerina Kochova, Elena Petrovska, Kristina Grncharoska*, Lidija Mano Iliev
Replek Farm Ltd., Kozle 188, 1000 Skopje, N. Macedonia

Validation and comparison of UV spexctrophotometry and HPLC methods for the determination of dissolution rate of Venlafaxine in Zanfexa 37.5mg tablets
Magdalena Atanasovski*, Sanja Hristovska, Stevche Petrovski, Gordana Mitrovska Evgenievska, Marija Stojanovska, Hristina Babunovska
Alkaloid AD, Blvd. Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

DRYLAB® software application for development of HPLC gradient method suitable for determination of three components in drug product
Marija Velichkovska*, Elena Balsikevska, Aleksandra Petrovska, Natasha Anevska Stojanovska, Jelena Lazova
Institute for Research and Development, Alkaloid AD-Skopje, Blv. Aleksandar Makedonski 12, 1000 Skopje, Macedonia

Automated determination of acid value on fatty alcohols and fatty acids raw materials using potentiometric titration
Marina Gjoshevska*, Marina Chachorovska, Katerina Runcevska
Research and Development, Alkaloid AD, Blvd. Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Critical Aspects of In Vitro Release (IVRT) method development for PEG based ointments
Mario Ignjatovic*, Natasha Karalija, Packa Antovska, Jelena Lazova
Research & Development, Alkaloid AD Skopje, Blvd. Aleksandar Makedonski 12, 1000 Skopje, North Macedonia

Measurement uncertainty over the concentration range for potentiometric titration of glycine
Elena Trajkoska Bojadjiska, Hrisanta Godzo, Gabriela Petrovska Dimitrievska,, Jelena Acevska, Aneta Dimitrovska,  Katerina Brezovska
Faculty of Pharmacy, University “Ss Cyril and Methodius”, Mother Theresa 47, 1000 Skopje, Republic of N. Macedonia

Method suitability validation for determination of microbiological purity of Ibuprofen film coated tablets 400 mg
Damjan Shushleski*, Marjan Velkovski, Irena Slaveska Spirevska, Elena Metcheva, Silvana Ristevska, Tatjana Dimitrieva
Replek Farm, st. Kozle 188, 1000 Skopje, N. Macedonia

Cleaning validation in production area – development of analytical method for quantitative determination of Cefixime residues
Miona Manasova1*, Elena Bilbilovska1, Biljana Markoska Janevski1, Jelena Acevska 2, Gordana Mitrovska1, Hristina Babunovska1
1Alkaloid AD Skopje, Blvd.Aleksandar Makedonski 12, 1000 Skopje, North Macedonia
2Faculty of Pharmacy, Ss.Cyril and Methodius University, Mother Teresa 47, 1000 Skopje, North Macedonia

Ongoing process verification in Alkaloid
Andrijana Markoska, Verica Marinova, Ana Sudjukovikj, Marija Trenchevska, Katerina Aleksievska Beldedovska, Elizabeta Karadzinska, Maja Velinovska Cadinoska, Milena Dobrkovic Shotarovska, Andrea Alagjozovska, Gordana Evgenievska Mitrovska, Olivera Paneva
Alkaloid AD, Pharmaceutical, Chemical and Cosmetics Company, Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Development and validation of ICP-OES method for determination of elemental impurities in some opiаtе alkaloids
Mirjana Bogdanoska Mircheska1*, Katerina Janchevska1, Petre Makreski2
1Research and Development, Alkaloid AD, Blvd. Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia
2Institute of Chemistry, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University in Skopje, Arhimedova 5, 1000 Skopje, Republic of North Macedonia

Forced degradation of timolol maleate on high temperature for verification of HPLC method for related substances in Timolol eye drop 0.5%
Aleksandra Veleska Stojanovska1, Tijana Serafimovska2, Marija Darkovska Serafimovska1
1Faculty of Medical sciences, University “Goce Delcev”, Krste Misirkov No.10-A, 2000 Stip, North Macedonia
2Faculty of Pharmacy, University “Ss. Cyril and Methodius”, Mother Tereza 47, 1000 Skopje, North Macedonia

Risk assessment study of potential elemental impurities in montelukast film coated tablets
Stefan Angelevski1, Irena Slaveska Spirevska1, Elena Lazarevska Todevska1, Tanja Bakovska Stoimenova1, Marija Glavash Dodov2, Maja Simonoska Crcarevska2, Renata Slaveska Raichki2
1Replek Farm Ltd., Kozle 188, 1000, Skopje, N. Macedonia
2Faculty of Pharmacy, “Ss. Cyril and Methodius” University in Skopje, St.“Mother Teresa” 47, 1000 Skopje, N. Macedonia

A validated isocratic RP-HPLC method for determination of linezolid in pharmaceutical dosage forms
Zana Mustafa1*, Shaban Memeti1,2,3, Dragica Doneva1, Katerina Starkoska1, Maja Shishovska1, Zharko Tanturovski1, Sanija Zulfikjari1, Aleksandra Dimitrovska1, Zorica Arsova-Sarafinovska1,4
1Institute of Public Health of Republic of North Macedonia, 50-ta Divizija 6, 1000 Skopje, Republic of North Macedonia
2Medical Faculty, University Ss. Cyril and Methodius, 50-ta Divizija 6, 1000 Skopje, Republic of North Macedonia
3University Clinic for Pediatric Surgery, 50-ta Divizija 6, 1000 Skopje, Republic of North Macedonia
4Faculty of Medical Sciences, University Goce Delchev, Krste Misirkov No 10-A, 2000 Stip, Republic of North Macedonia

Evaluation of chromatographic conditions for simultaneously determination of Emtricitabine and Tenofovir
Dragica Doneva1, Maja Shishovska1., Zana Mustafa1*, Shaban Memeti1,2,3, Katerina Starkoska1, Sanija Zulfikjari1, Aleksandra Dimitrovska1, Zorica Arsova-Sarafinovska1,4
1Institute of Public Health of Republic of North Macedonia, 50-ta Divizija 6, 1000 Skopje, Republic of North Macedonia
2Medical Faculty, UniversitySs. Cyril and Methodius, 50-ta Divizija 6, 1000 Skopje, Republic of North Macedonia
3University Clinic for Pediatric Surgery, 50-ta Divizija 6, 1000 Skopje, Republic of North Macedonia
4Faculty of Medical Sciences, Goce Delchev University, KrsteMisirkov No 10-A, 2000 Stip, Republic of North Macedonia

Extraction and Interaction study by HPLC-DAD method for screw cap PP 28 child-resistant used in packaging of drug product
Marija Mojsovska*, Marija Arsova, Natasha Anevska – Stojanovska
Institute for Research and Development, Alkaloid AD-Skopje, Blv. Aleksandar Makedonski 12, 1000 Skopje, Macedonia

Optimization of ion-suppression reverse phase-separation of basic compounds using different mobile phases
Gabriela Petrovska-Dimitrievska*, Jelena Acevska, Marija Zafirova Gjorgievska, Liljana Ugrinova, Natalija Nakov, Vasil Karcev, Aneta Dimitrovska, Katerina Brezovska
Center for Drug Quality Control, Faculty of Pharmacy, Ss. Cyril and Methodius University, Majka Tereza 47, 1000 Skopje, Republic of North Macedonia

Regulatory Approaches of EMA and FDA for accelerated approval of marketing-authorisation application
Kristina Kjurchieva Peno1, Aneta Dimitrovska2, Jasmina Tonic Ribarska2, Ana Poceva Panovska2, Katerina Brezovska2
1Agency for medicines and medical devices, Ss Cyril and Methodius No.54, 1000 Skopje, R. North Macedonia
2Faculty of Pharmacy, University Ss. Cyril and Methodius, Majka Tereza 47, 1000 Skopje, R. North Macedonia

Comparison of post-authorization processes between EMA and FDA
Marija Brezovska, Jelena Acevska, Natalija Nakov, Liljana Ugrinova, Jasmina Tonic Ribarska
Institute for Applied chemistry and Pharmaceutical analysis, Faculty of Pharmacy, University Ss. Cyril and Methodius, Majka Tereza 47, 1000 Skopje, North Macedonia

Selection of membrane filter for in vitro release test method for PEG-based ointment
Filip Gogu*, Ana Atanasova, Veronika Popovska Jakimovska, Maja Stevanoska, Packa Antovska, Jelena Lazova
Research and Development, ALKALOID AD, Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Optimization for method for elemental impurities in ultra-pure waters
Cvetanka Janakieva Bashevska*, Darko Bachvarovski, Bisera J. Trajkovska, Andrea Alagjozovska, Tatjana Bogovska, Hristina Babunovska
ALKALOID AD-Skopje, Pharmaceutical, Chemical and Cosmetics Company Aleksandar Makedonski 12, 1000 Skopje, Macedonia

Synergistic effects of terpenes and cannabinoids evaluated through antimicrobial activity
Tijana Serafimovska1, Jasmina Tonic Ribarska2, Gjoshe Stefkov2, Marija Mitevska3, Zlatko Keskovski3, Sasho Stefanoski3, Marija D. Serafimovska1,3, Biljana Gjorgeska1
1Faculty of Medical sciences, University “Goce Delcev”, Krste Misirkov No.10-A, 2000 Stip, North Macedonia
2Faculty of Pharmacy, University “Ss. Cyril and Methodius”, Mother Tereza 47, 1000 Skopje, North Macedonia
3NYSK Holdings, 112 Str. No.217, Kjojlija, Municipality Petrovec, 1000 Skopje, North Macedonia

A study on the compatibility of Ibuprofen with some essential oils used for formulation of semi-solid pharmaceutical dosage forms for topical use
Elena Cvetkovska Bogatinovska*, Monika Stojanovska Pecova, Mirjana Bogdanoska Mircheska, Marina Chachorovska
Alkaloid AD, Blvd. Aleksandar Makedonski 12, 1000 Skopje, North Macedonia

Evaluation of ongoing stability data for Zolpidem film coated tablets using statistical methods for trending analysis
Ana Vavlukis*, Dragana Kafedziska, Milosh Todorovski, Sanja Despotovska, Hristina Babunovska
ALKALOID AD-Skopje, Pharmaceutical, Chemical and Cosmetics Company, Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Discriminatory power of an in-house developed method for in vitro release test (IVRT) used for analyzing topical product
Antonela Bojkovska, Magdalena Velichkovska, Filip Smilchevski, Ema Ilievska Vidanovska, Blagica Manchevska, Sonja Dimchevska, Packa Antovska1, Jelena Lazova
Research and Development, ALKALOID AD, Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Benefits from paperless computer system validation in pharmaceutical industry
Nikola Simonovski1, Biljana Gjorgjeska2
1ALKALOID AD Skopje, Blvd. A.Makedonski 12, 1000 Skopje, N.Macedonia
2University Goce Delchev, Faculty of Medical Sciences, Ljuben Ivanov 25, 2000 Stip, N.Macedonia

Regulatory Opportunities Investigations -requirements and procedures for medicines registration in the EAEU and opportunities
Ljuba Karanakov, Katerina Zafirova Georgievska, Ana Zisovska Beleva, Julijana Dimovska, Svetlana Neceva
Regulatory Affairs Department, Replek Farm Ltd. Skopje, Kozle str. 188, 1000 Skopje, Republic of North Macedonia

Elucidation of molecular structure of bromazepam opened ring related compound detected in bromazepam tablets in acidic dissolution media using LC/MS
Viktorija Jakimovska Pokupec*, Katerina Janchevska, Marija Grozdanovska, Viktorija Petrovska
Research and Development, Alkaloid AD, Blvd. Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Change in the primary packaging of tablets from glass bottle to blister
Ana Ivcheska*, Ivana Trajkova*, Natasha Kronevska, Elizabeta Karadzinska, Olivera Peneva
ALKALOID AD Skopje, Pharmaceutical, Chemical and Cosmetics Company, Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Root causes for presence of Nitrosamine impurities in drug substances and drug products
Milena Prculovska1, Jelena Acevska2, Ana Poceva Panovska2, Natalija Nakov2, Aneta Dimtirovska2, Katerina Brezovska2.
1REPLEK FARM Ltd., Quality Control Department, Kozle No. 188, 1000 Skopje, R.N. Macedonia
2Institute of Applied Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy, University Ss. Cyril and Methodius, Majka Tereza 47, 1000 Skopje, R.N. Macedonia

Understanding the requirements of the MDR 2017/745 regarding person responsible for regulatory compliance
Ajra Sinanova*, Lora Atanasovska, Marija Davceva Jovanoska, Elizabeta Karadzinska1, Nada Popstefanova, Olivera Paneva
Pharmaceutical Chemical Cosmetic Industry ALKALOID AD Skopje, Blvd. Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Consultation with target patient groups: User (Readability) testing/bridging procedure
Gordana Damjanovska
REPLEK FARM Ltd, Kozle 188, 1000 Skopje, Republic of North Macedonia

Surfactant-based potentiometric method for quantification of sildenafil citrate
Hrisanta Godzo*, Natalija Nakov, Gabriela Petrovska-Dimitrievska, Marija Zafirova Gjorgievska, Jasmina Tonic Ribarska, Katerina Brezovska
Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje, Mother Theresa 47, 1000 Skopje, Republic North Macedonia

Implementation of the Ph. Eur. suitability test for semi-micro determination of water
Biljana Atanasovska*, Jelena Acevska, Natalija Nakov
Faculty of Pharmacy, University “Ss Cyril and Methodius”, Majka Tereza 47, 1000 Skopje, Republic of North Macedonia

Potentiometric determination of calcium content with combined Cu ISE and reference Ag/AgCl electrode in API
Dragana Trajkovikj*, Nenad Dimitrovski, Bisera Janeska Trajkovska, Aleksandra Manasieska, Nora Doci, Cvetanka Janakieva Bashevska, Mena Ivanoska Zdravkovska
ALKALOID AD-Skopje, Pharmaceutical, Chemical and Cosmetics Company, Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Practical examples of implementation of the Unique Device Identifier (UDI) requirements for Medical Devices
Dragica Trpkoska*, Natasha Vukikjevikj.
Pharmaceutical Chemical Cosmetic Industry ALKALOID AD Skopje, Blvd. Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Re-validation during method transfer examples in Official medicines control laboratories
Marija Zafirova Gjorgievska*, Gabriela Petrovska-Dimitrovska, Vasil Karchev, Hrisanta Godzo, Olga Gigopulu, Liljana Ugrinova
Center for Drug Quality Control, Faculty of Pharmacy, Ss. Cyril and Methodius University, Majka Tereza 47, 1000 Skopje, Republic of North Macedonia

Development of RP HPLC method with gradient elution for simultaneous Resveratrol and Vitamin E determination in solid dosage forms
Marina Topkoska*1, Martina Miloshevska1, Marjan Piponski1, Elena Lazarevska Todevska1, Irena Slaveska Spirevska1, Jelena Acevska2
1REPLEK FARM Ltd, Quality Control Department, Kozle No.188, 1000 Skopje, R. Macedonia
2Faculty of Pharmacy, Ss. Cyril and Methodius University, Mother Theresa 47, 1000 Skopje, R.N. Macedonia

Risk analysis for the presence of pesticides in dry cannabis floss cultivated under indoor conditions
Maja Trenova, Tijana Serafimovska, Tanja Ivanova , Suzana Zafirova, Marija Darkovska Serafimovska
Faculty of Medical sciences, University “Goce Delcev”, Krste Misirkov No.10-A, 2000 Stip, North Macedonia

Risk evaluation and assessment for the presence of nitrosamine impurities in Alkaloid Losartan film coated tablets
Toni Camurovski, Vanja Bobevska, Sonja Spirovska Burčevska, Jasmina Kimovska, Nada Popstefanova, Verče Jovanovska Jankovska, Elizabeta Karadžinska, Olivera Paneva, Ksenija Brzilova, Maja Velinovska Cadinovsa
ALKALOID AD Skopje, Blvd. Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Risk Management and Business Continuity of Alkaloid AD Skopje
Nada Popstefanova, Verče Jovanovska Jankovska, Sonja Spirovska Burčevska, Jasmina Kimovska, Vanja Bobevska, Olivera Paneva, Elizabeta Karadžinska, Toni Camurovski, Ksenija Brzilova, Maja Velinovska Cadinovska, Sanja Uskokova
ALKALOID AD Skopje, Blvd. Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Screening the capability of ATR-FTIR for simultaneous quantification of Vitamin B1, B6 and B12 in powder blend
Apostol Todorovski, Marina Petreska, Keti Shapkovska, Nikola Geskovski, Jelena Acevska
1Bionika Pharmaceuticals, Skupi 57, 1000 Skopje, R.North Macedonia
2Faculty of Pharmacy, SS. Cyril and Methodius University, Mother Teresa 47, 1000 Skopje, R.North Macedonia

Serialization, defending the medicinal products for human use from counterfeiting
Maja Velinovska Cadinoska*, Maja Lazarova*, Irma Mirceska*, Igor Dimitrievski, Darko Projceski, Mila Palamidovska, Darko Atanasoski, Elizabeta Karadzinska, Vlatko Lazarov, Nikola Dimovski, Natasha Vukicevic, Milkica Gligorova, Olivera Paneva
Alkaloid A.D, Blvd. Aleksandar Makedonski 12, 1000 Skopje, N. Macedonia

Systematic approach for proper control chart design for Karl-Fischer titrator
Blagoj Achevski*, Frosina Arsova, Jelena Acevska, Jasmina Tonikj-Ribarska, Katerina Brezovska, Natalija Nakov
Faculty of Pharmacy, University “Ss Cyril and Methodius”, 1000 Skopje, Republic of North Macedonia

Trending environmental monitoring data, analysis and data management for non-sterile pharmaceutical manufacturing
Hristina Sekuloska*, Apostol Todorovski, Marina Petreska
Quality Control Department, Bionika Pharmaceuticals, str. Skupi 57, 1000 Skopje, North Macedonia

The difference between verification and validation of analytical methods in the pharmaceutical industry
Suzana Zafirova, Tijana Serafimovska, Maja Trenova, Tanja Ivanova, Marija Darkovska Serafimovska
Faculty of Medical sciences, University Goce Delcev, address:Krste Misirkov No.10-A P.O. Box 201, 2000 Shtip, Republic of North Macedonia

Registration of medicinal products for pediatric use and Pediatric Investigation Plan
Violeta Bibovska1, Natasha Vukicevic1, Jasmina Tonikj Ribarska2, Suzana Trajkovikj Jolevska2
1Alkaloid AD Skopje, Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia
2University Ss Cyril and Methodius, Faculty of Pharmacy, 1000 Skopje, Republic of North Macedonia

Workflow for investigation of Out of Specification results in physico-chemical laboratory in Alkaloid
Andrea Alagjozovska, Milena Dobrkovikj Shotarovska, Maja Mindoseva, Stefan Petrovski, Gordana Mitrovska, Sanja Despotovska, Ornela Kuzmanovska, Elizabeta Karadzinska, Olivera Paneva
Alkaloid AD, Pharmaceutical, Chemical and Cosmetics Company, Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Principles and methods used in the serialization process of the medicines
Ivona Trajanovska1, Biljana Pavicevic1, Katerina Brezovska2, Suzana Trajkovic Jolevska2, Jasmina Tonik Ribarska2
1Alkaloid A.D., blvd. Aleksandar Makedonski12, 1000 Sкопје, N.Macedonia
2Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje, Majka Tereza 47, 1000 Skopje, N.Macedonia

Deviations during life cycle of medicines and taking activities for risk elimination on the characteristics of the finished product
Monika Milanovska*, Ornela Kuzmanovska*, Olivera Paneva, Elizabeta Karadzinska, Biljana Dimovska, Elizabeta Atanaskova, Natasha Kitanovska, Tatjana Spancevska Kaeva
Alkaloid AD Skopje, Aleksandar Makedonski Boulevard 12, 1000 Skopje, Republic of North Macedonia

Pharmacovigilance audit (“remote”) of the pharmacovigilance system of Replek Farm by an EU partner
Marina Bakalinova, Angelina Zimbakova, Jasna Bosnjakovska, Sonja Iceva Doneva, Svetlana Neceva
Regulatory Affairs Department, Replek Farm Ltd. Skopje, 188 Kozle, 1000 Skopje, Republic of North Macedonia

A review of published cases of severe cutaneous reactions associated with the use of the most frequently prescribed antiepileptic drugs
Simona Atanasovska*, Vladimir Kostovski, Irina Dukovska Teova, Sofija Dimkoska, Emilija Filipovska, Kristina Najdova, Ivona Trpenoska Aleksovska, Marija Panajotovikj Pop-Nikolova, Ace Kuzmanovski, Sandra Chomovska – Madevska
Global Pharmacovigilance, Alkaloid AD Skopje, Blvd. “Aleksandar Makedonskiˮ 12, 1000 Skopje, North Macedonia

Transfer and optimization of methods for particle size distribution from Mastersizer 2000 to Mastersizer 3000
Metodi Trajcev*, Cvetanka Janakieva Bashevska, Hristina Tomovska, Tatjana Bogovska, Hristina Babunovska
ALKALOID AD-Skopje, Pharmaceutical, Chemical and Cosmetics Company, Aleksandar Makedonski 12, 1000 Skopje, Macedonia

Fc-fusion proteins: therapeutic relevance and quality assessment
Gent Misini1, Nebija Dashor2*, Rumenka Petkovska1, Natalija Nakov1
1Faculty of Pharmacy, University Ss Cyril and Methodius in Skopje, 1000 Skopje, Republic of North Macedonia
2Faculty of Medicine, University Clinical Center n.n. 10000 Pristina, Kosovo

Continued Process Verification
Natalija Misajlovska
Alkaloid AD Skopje, blvd. Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Extensive underreporting and insufficient quality of incident reports received from pharmacists in Croatia from 2012 to 2021
A. Šimunović , K. Kranjčec, S. Tomić
HALMED, Ksaverska cesta 4, Zagreb, Croatia

Quality management system and corporate quality assurance
Elizabeta Karadžinska*1, Marija Davčeva Jovanoska1, Maja Velinovska Čadinoska1, Verče Jovanovska Jankovska1, Sonja Spirovska Burčevska1, Nina Ekart Oman2, Viška Miceska3, Gabriela Gjorgjievska4, Nada Popstefanova1, Olivera Paneva1
1ALKALOID AD Skopje, Blvd. Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia
2Alkaloid INT, Slandrova ulica 4, 1231 Crnuče, Ljubljana, Republic of Slovenia
3Alkaloid d.o.o.Beograd, Prahovska 3 11000 Belgrade, Republic of Serbia
4Alkaloid KONS dooel, Blvd. Aleksandar Makedonski 12 1000 Skopje, Republic of North Macedonia

Risk-based contamination control strategy of manufacturing non-sterile pharmaceutical products
Martina Gjorgjevska*, Angela Nastevska, Stojne Tanevska
Bionika Pharmaceuticals, str. Skupi 57, 1000 Skopje, North Macedonia

SECTION: PHARMACEUTICAL TECHNOLOGY AND BIOTECHNOLOGY/BIOPHARMACY/COSMETOLOGY

Approaches for optimization of formulation and manufacturing process of low-dose tablets
Frosina Jovanovikj*, Isidora Miovska, Veronika Popovska Jakimovska, Filip Gogu, Maja Stevanoska, Ana Atanasova, Packa Antovska, Jelena Lazova
Research and Development, Alkaloid AD, Blvd. Aleksandar Makedonski 12, 1000 Skopje, North Macedonia

Key aspects in process design & scale up of semi-solid dosage forms from pilot to commercial batch size
Verka Nedanova, Elizabeta Ristevska Bogoevska, Natasa Anevska Stojanovska
Research and Development, Alkaloid AD, Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Selenium nanoparticles render pandrug-resistant Acinetobacter baumannii susceptible to colistin
Dušan Ušjak1,2, Katarina Novović3, Brankica Filipić1,3, Milan Kojić3, Nenad Filipović4, Magdalena M. Stevanović4, Nevena Arsenović-Ranin1, Marina T. Milenković1
1Department of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia
2Laboratory for Molecular Biology, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444/a, 11042 Belgrade, Serbia
3Laboratory for Molecular Microbiology, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444/a, 11042 Belgrade, Serbia
4Institute of Technical Sciences of the Serbian Academy of Sciences and Arts, Knez Mihailova 35/IV, 11000 Belgrade, Serbia

Evaluation of influence of different manufacturing technologies on impurity profile of immediate release formulation comprising highly degradable ACE inhibitor as model active substance
Tamara Ivanoska*, Maja Hadzieva-Gigovska, Marina Chachorovska, Oja Ali Memed
Research & Development, Alkaloid AD-Skopje, Blvd. Aleksandar Makedonski 12, 1000 Skopje, N. Macedonia

Selection of filter for sterilization using process of membrane filtration based on potential adsorption of Benzalkonium chloride on filter membranes
Viktorija Penshovska*, Elizabeta Atanaskova, Ivana Cholakova, Natasa Anevska Stojanovska, Veronika Angelovska, Marija Mojsovska
Research and development department, Alkaloid AD, Blvd. Aleksandar Makedonski 12, 1000, Skopje, Republic of North Macedonia 

Scale Up of Semisolid dosage forms in Manufacturing Processes
Keti Shapkovska, Bojan Papadinov, Nade Bogovska, Aleksandar Donchevski
Bionika Pharmaceuticals, Skupi 57, 1000, Macedonia

Root cause analysis regarding formation of N-nitrosodimethylamine impurity in drug product containing API with reactive amines
Monika Koviloska*, Katerina Tnokovska, Packa Antovska, Jelena Lazova
Research & Development, ALKALOID AD, Blvd. Aleksandar Makedonski 12, 1000 Skopje, R. N. Macedonia

Raman spectroscopy: a versatile and accurate technique that showcases solutions in diagnostics and in nanomedicine
Filip Gorachinov1, Petre Makreski2, Katerina Goracinova1, Nikola Geskovski1
1Faculty of Pharmacy, Ss. Cyril and Methodius University of Skopje, 1000 Skopje, North Macedonia
2Institute of Chemistry, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University in Skopje, 1000 Skopje, North Macedonia

Smart contact lenses: How far has glaucoma treatment gone?
Ognjenka Rahić1, Jasmina Hadžiabdić1, Amina Tucak-Smajić1, Merima Sirbubalo1, Lamija Hindija1, Marija Glavaš-Dodov2, Edina Vranić1*
1University of Sarajevo – Faculty of Pharmacy, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina
2Faculty of Pharmacy, University Ss. Cyril and Methodius, Majka Tereza 47, 1000 Skopje, N. Macedonia

Influence of the drug particle morphology on physical characteristics of granules prepared with wet granulation technology process
Biljana Temelkovska*, Dejan Kuneski, Kristina Angelovska, Sonja Dimcevska, Packa Antovska, Sonja Ugarkovic
Research and development, Alkaloid AD, Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Spray-dried snail mucus as raw material with potential for chronic wound treatment
Teodora Tasevska1, Marija Glavas Dodov1, Dushko Shalabalija1, Ljubica Mihailova1, Radmil Polenakovic2, Maja Simonoska Crcarevska1
1Institute of Pharmaceutical Technology and Center of pharmaceutical nanotechnology, Faculty of Pharmacy, Ss. Cyril & Methodius University in Skopje, Majka Tereza 47, 1000 Skopje, R. North Macedonia
2Institute for production engineering and management, Faculty of Mechanical engineering, Ss. Cyril & Methodius University in Skopje, Rudger Boshkovikj 18, 1000 Skopje, R. North Macedonia

The effect of critical process parameters in manufacturing (filling process) of dry powders for oral suspensions
Maja Stojanoska1*, Marina Todorovska Ackovska1, Krume Toshev1, Katerina Goracinova2, Marija Glavas Dodov2
1Alkaloid AD-Skopje, Pharmaceutical, Chemical and Cosmetics Industry, Blvd. Partizanski Odredi 98A, 1000 Skopje, N. Macedonia
2Institute of Pharmaceutical technology, Faculty of Pharmacy, Ss Cyril and Methodius University, Majka Tereza 47, 1000 Skopje, N. Macedonia

Influence of mannitol and sorbitol on the in vitro dissolution of a model poorly water-soluble drug
Natalija Dimovska*, Ana Smileva, Biljana Keleshovska, Liljana Makraduli
Replek, Kozle 188, 1000 Skopje, North Macedonia

Effect of isopropyl alcohol and poloxamer 407 on gelation temperature and critical quality attributes of thermo-reversible gel formulation
Lile Zdraveska1*, Nikola Jovanovikj1, Roza Markovski2, Iva Antova1, Mario Ignjatovikj1, Packa Antovska1, Jelena Lazova1
1Research & Development, ALKALOID AD, Blvd. Aleksandar Makedonski 12, 1000 Skopje, R. N. Macedonia
2IMCD Deutschland GmbH, Konrad-Adenauer-Ufer 41-45, 50668 Cologne, Germany

Stability study of 188Re-HEDP as a radionuclide therapeutical for bone pain palliation
Toni Tripunoski, Sinisa Stojanoski, Sonja Kuzmanovska*
Institute of Pathophysiology and Nuclear Medicine, Medical Faculty, Ss Cyril and Methodius University, Mother Theresa 17, 1000 Skopje, Republic of North Macedonia

Preparation of 188Re-HEDP as a bone tumor radionuclide therapeutic
Toni Tripunoski, Ana Ugrinska, Sonja Kuzmanovska*
Institute of Pathophysiology and Nuclear Medicine, Medical Faculty, Ss Cyril and Methodius University, Mother Teresa 17, 1000 Skopje, Republic of North Macedonia

Influence of formulation and process variables on physical characteristics and dissolution behavior of controlled release matrix tablets
Monika Kostovska*, Marija Mojsovska, Nadica Vanova, Krume Toshev, Natasa Anevska-Stojanovska
Research and Development, ALKALOID AD Skopje, Bvld Aleksandar Makedonski, 1000 Skopje, R.N. Macedonia

Excipients in pediatric dosage forms and related regulatory aspects with review to propylene glycol
Hristina Pislevikj*, Katerina Goracinova
Faculty of Pharmacy, Ss. Cyril and Methodius University, Mother Theresa 47, 1000 Skopje, N. Macedonia

Influence of different concentration of polysorbate 20 and carbomer on suspension structure
Vesna Savić1*, Milica Martinović1, Ivana Nešić1, Keti Nonevska Vaneva2, Petar Jovanović3
1Department of Pharmacy, Faculty of Medicine, Blvd. Dr Zorana Djindjica 81, 18108 Nis, Republic of Serbia
2Messer Vardar Tehnogas, Istočna industrijska zona BB 1040, Skoplje
3Petrapharm, Lava Tolstoja bb, Pirot, Republic of Serbia

Correlation between in vitro and in silico determined sun protection factor of selected UV filters
Milica Martinović1*, Vanja Tadić2, Ivana Nešić1
1Department of Pharmacy, Faculty of Medicine, Blvd. Dr Zorana Djindjica 81, 18108 Nis, Republic of Serbia
2Institute for Medicinal Plant Research “Dr. Josif Pancic”, Tadeusa Koscuska 1, 11000 Belgrade, Serbia

Investigation of sensory characteristics of cosmetic emulgels containing different vitamin C derivatives
Aleksandra Stolić Jovanović*1, Milica Martinović2, Ivana Nešić2
1“Filly Farm” Pharmacy, Miloša Velikog bb, 11320 Velika Plana, Republic of Serbia
2 Department of Pharmacy, Faculty of Medicine, University of Niš, 81 Dr Zoran Đinđić Boulevard, 18000 Niš, Republic of Serbia

Covalent functionalization of hybrid multi-walled carbon nanotube-graphene with polyethileneglycol for targeted delivery of Temozolomide
Radmila Milenkovska1*, Nikola Geshkovski1, Petre Makreski2, Emil Popovski2, Anita Grozdanov3, Zoran Gavrilov1, Kristina Mladenovska1
1Faculty of Pharmacy, University Ss Cyril and Methodius in Skopje, Majka Tereza 47, 1000 Skopje, N. Macedonia
2Faculty of Natural Sciences and Mathematics, University Ss Cyril and Methodius, 1000 Skopje, N. Macedonia
3Faculty of Technology and Metallurgy, University Ss Cyril and Methodius, 1000 Skopje, N. Macedonia

Physiologically based in silico modeling of a model BCS class II antipsychotic drug following oral administration
Aleksandra Krstevska1,2*, Svetlana Ibrić2, Sandra Cvijić2
1Alkaloid AD Skopje, Blvd. Aleksandar Makedonski 12, 1000 Skopje, North Macedonia
2Department of Pharmaceutical Technology and Cosmetology, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11221, Belgrade, Serbia

Method optimization for viscosity measurement of cutaneous solution
Ivana Cholakova*, Elizabeta Atanaskova, Viktorija Penshovska, Natasha Anevska Stojanovska
Research and development department, Alkaloid AD, Buld. Aleksandar Makedonski 12, 1000 Skopje, N.Macedonia

Selection of appropriate manufacturing technology for development of Oxycodone prolonged release film-coated tablets using QbD approach
Oja Memed1*, Maja Hadzieva-Gigovska1, Maja Simonoska Crcarevska2, Marija Glavas Dodov2
1Research & Development, Alkaloid AD-Skopje, Blv. Aleksandar Makedonski 12, 1000 Skopje, North Macedonia
2Center for Pharmaceutical Nanotehnology, Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje, Majka Tereza 47, 1000 Skopje, North Macedonia

Influence of organic to aqueous phase solvent volume ratio on the physicochemical characteristics of rosuvastatin and ezetimibe loaded lipid-polymer hybrid nanoparticles prepared by nanoprecipitation method
Nadica Vanova Nakjinova1,2, Nikola Jovanovikj1,2, Zoran Kavrakovski1, Nikola Geshkovski1, Kristina Mladenovska1
1Faculty of Pharmacy, Ss. Cyril and Methodius University, Majka Tereza 47, 1000, Skopje, Republic of N Macedonia
2Research and Development, Alkaloid AD, Pharmaceutical Chemical and Cosmetics Company, Aleksandar Makedonski 12, 1000 Skopje, Republic of N Macedonia

Comparative analysis of the tabletting process between single rotary tablet press and double rotary tablet press
Iva Gacevska*, Meri Davceva
Alkaloid AD, Pharmaceutical, Chemical and Cosmetics Company, Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia

Impact of qualitative formulation variables on critical quality attributes of tablets with fast disintegration
Krume Toshev*, Ivana Endekovska, Monika Kostovska, Veronika Angelovska, Natasa Anevska Stojanovska
Research and Development, Alkaloid AD, Blvd Aleksandar Makedonski 12, 1000 Skopje, R.N. Macedonia

Formulation and in-vitro evaluation of prolonged-release matrix tablets
Kristina Angelovska*, Sonja Dimchevska, Dejan Kuneski, Biljana Temelkovska, Blagica Manchevska, Packa Antovska, Sonja Ugarkovic
Research & Development, ALKALOID AD, Blvd. Aleksandar Makedonski 12, 1000 Skopje, R.N. Macedonia

Influence of punch diameter change on the quality attributes of tablets
Simona Boshkova*, Monika Kostovska, Krume Toshev, Natasha Anevska Stojanovska
Research & Development, Alkaloid AD, Blvd. Aleksandar Makedonski 12, 1000 Skopje, R. N. Macedonia

Influence of lubricant glycerol dibehenate concentration on dissolution stability and tablet properties
Ivana Endekovska*, Krume Toshev, Julija Hristovska, Natasa Anevska Stojanovska
Research & Development, ALKALOID AD, Blvd. Aleksandar Makedonski 12, 1000 Skopje, R.N. Macedonia

Improving the dissolution rate of Nebivolol hydrochloride by using nonionic surfactant and polymer combination
Biljana Keleshovska*, Natalija Dimovska, Ana Smileva, Dobrinka Dimova
Replek Farm, Kozle 188, 1000 Skopje, North Macedonia

Nanoemulsions: a new trend in transdermal drug delivery
Jasmina Hadžiabdić1, Almina Šećkanović1, Ognjenka Rahić1, Lamija Hindija1, Merima Sirbubalo1, Amina Tucak-Smajić1, Marija Glavaš-Dodov2, Edina Vranić1*
1University of Sarajevo – Faculty of Pharmacy, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina
2Faculty of Pharmacy, University Ss. Cyril and Methodius, Majka Tereza 47, 1000 Skopje, N. Macedonia

Fun-shaped oral dosage forms for the pediatric population fabricated by digital light processing (DLP) 3D printing technique
Ivana Adamov1*, Jovana Živanović1, Ivana Verovski1, Natalija Arsović1, Nikola Pešić1, Djordje Medarević1, Branka Grujić2, Svetlana Ibrić1
1Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Belgrade
2Galenika AD, Batajnički drum b.b. Zemun, Belgrade

Design of Experiments (DoE) based determination of critical production variables in the manufacturing process of fixed-dose combination (FDC) drug containing Paracetamol
Elizabeta Atanaskova*, Ivana Cholakova, Viktorija Penshovska, Natasa Anevska Stojanovska
Research and development department, Alkaloid AD, Blvd. Aleksandar Makedonski 12, 1000 Skopje, Republic of North Macedonia 

Production of dry Cannabis flowers as starting material (active pharmaceutical substance in herbal form)
Katerina Arsova Manchevska* and Marija Glavas Dodov*
Institute of Pharmaceutical Technology, Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje, Majka Tereza 47, 1000 Skopje, North Macedonia

Pharmaceutical and technological characteristics of barium sulphate tablets -the screening of various formulation factors
Branka Grujić1*, Vesna Jelić1, Đorđe Medarević2
1R&D, Galenika, Batajnicki drum bb, 11080 Belgrade, Republic of Serbia
2Faculty of Pharmacy, Vojvode Stepe350, 11000, Belgrade, Republic of Serbia

Resolving tableting challenges and optimization of the tablet compression step of an immediate-release analgesic formulation
Angela Mirchevska*, Sonja Dimchevska, Kristina Angelovska , Packa Antovska
Research & Development, Alkaloid AD, Blvd. Aleksandar Makedonski 12, 1000 Skopje, R. N. Macedonia

Characterization of honey bee venom from Spilje, Debar region, N. Macedonia
Amdi Alili1, Elena Cvetkovska Bogatinovska2, Darko Stojanov2, Gabriela Petrovska Dimitrievska1, Hrisanta Godzo1, Dusko Shalabalija1, Katerina Goracinova1, Renata Slaveska Raicki1, Metodija Trajcev3, Marija Glavas Dodov1
1Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje, Majka Tereza 47, 1000 Skopje, N. Macedonia
2Research and Development, Alkaloid AD, Blvd. Aleksandar Makedonski 12, 1000 Skopje, North Macedonia
3Faculty of Agricultural Sciences and Food, Ss. Cyril and Methodius University in Skopje, Blvd. Aleksandar Makedonski bb, 1000 Skopje, N. Macedonia

Production of 2-[18F]Fluoro-2-deoxy-D-glucose radiopharmaceutical at the University Institute of Positron Emission Tomography, Skopje
Maja Velichkovska*, Katerina Kolevska, Marija Atanasova Lazareva, Maja Chochevska, Filip Jolevski, Ana Ugrinska
University Institute of Positron Emission Tomography, 1000 Skopje, North Macedonia

Validation of baby cream production process
Natasa Gjorgieva*, Ina Manchevska, Julija Gjorchevska Aceska, Dobrila Sekulovska Popovska
Production Cosmetics, Alkaloid AD Skopje, Aleksandar Makedonski 12, 1000, Skopje, Republic of North Macedonia

The importance of overall equipment effectiveness (OEE) in demonstrating control and consistency of pharma packaging process
Violeta Dinić Milisavljević, Vlada Petrović
Alkaloid DOO Beograd, Prahovska 3, 11000 Beograd, R. Serbia

SECTION: CLINICAL BIOCHEMISTRY-TOXICOLOGY-FOOD AND NUTRITION

Proteomic markers in breast cancer diagnosis and treatment
Filip Djokoski*; Таtјаnа Kadifkova Panovska; Marija Hiljadnikova-Bajro
Faculty of Pharmacy, Institute of Applied Biochemistry, Ss. Cyril and Methodius University in Skopje, Mother Theresa 47, 1000 Skopje, Republic of North Macedonia

Novel insights in pharmacomicrobiomics
Filip Djokoski*; Marija Hiljadnikova-Bajro
Faculty of Pharmacy, Institute of Applied Biochemistry, Department of Clinical Biochemistry, Ss. Cyril and Methodius University, Majka Tereza 47, 1000 Skopje, Republic of North Macedonia

Side effects associated with chlorhexidine mouthwashes use
Petrovski MIhajlo1; Terzieva-Petrovska Olivera1; Tashkov Tamara2*; Papakoca Kiro1
1Faculty of medical Sciences, Goce Delcev University, Krste Misirkov BB, 2000 Stip, Republic of North Macedonia
2Clinical hospital Stip, Ljuben Ivanov BB, 2000, Stip

Scientific potential of the salivary proteome in clinical management of Diabetes Mellitus
Angela Simovska*; Marija Hiljadnikova-Bajro
Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje, Bul. Mother Teresa, no. 47, 1000 Skopje, Republic of North Macedonia

The effect of Coenzyme Q10 in Cisplatin induced myelosuppression in rats
Emilija Shikole1*; Icko Gjorgoski2; Marija Glavas Dodov3; Nedica Kocheva3; Jasmina Trojachanec1; Dimche Zafirov1
1Institute for Preclinical and Clinical Pharmacology with Toxicology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 50th Divizija No. 6, 1000 Skopje, North Macedonia
2Institute of Biology, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University in Skopje, Arhimedova St. 5, 1000 Skopje, North Macedonia
3Center of Pharmaceutical nanotechnology, Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje, Mother Theresa 47, 1000 Skopje, North Macedonia

Preservation of traditional knowledge related to plant biodiversity
Suzana Apostolovska1*; Biljana Bauer Petrovska2
1Public Health Institution, Health Center ,,Dr. Haim Abravanel”, str. Philip II 9, 7000 Bitola, R. N. Macedonia
2Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje, str. Mother Tereza 47, 1000 Skopje, R. N. Macedonia

Effect of magnesium citrate on iron status parameters: an interventional study
Neda Milinković1*; Nevena Ivanović2; Ksenija Veličković3; Marija Sarić Matutinović1; Brižita Đorđević2; Branimir Radosavljević4; Svetlana Ignjatović1,5
1Department of Medical Biochemistry, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, Serbia
2Department of Bromatology, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, Serbia
3Departmentof Cell and Tissue Biology, Faculty of Biology, University of Belgrade,11000 Belgrade, Serbia
4Institute of Chemistry in Medicine, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia
5Center for Medical Biochemistry, Clinical Center of Serbia, 11000 Belgrade, Serbia

Potential of liquid biopsy in diagnosis and monitoring of malignant invasion
Elena Pacheshkoska; Marija Hiljadnikova-Bajro
Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje, Mother Theresa 47, 1000 Skopje, Republic of North Macedonia

Retrospective study of intoxication-related deaths in Republic of North Macedonia, 2010-2020
Zorica Bozhinoska; Marija Bujaroska; Stefanija Ubavkova; Ana Ivcheva; Ljupco Cakar; Zlatko Jakovski; Verica Poposka
Institute of Forensic Medicine, Criminology and Medical Deontology, Medical Faculty, Ss. Cyril and Methodius University in Skopje, Mother Theresa 19, 1000 Skopje, Republic of North Macedonia

Evaluation of Tanacetum vulgare L. and Juniperus communis L. biocompatibility limitations in eukaryotic cells
Kristina Shutevska*1; Zoran Zhivikj1; Sevda Sofronievska1; Ana Marija Bajatovska1; Marija Karapandzova2; Ivana Cvetkovikj Karanfilova2; Nadica Trajkovska2; Tanja Petreska Ivanovska1; Tatjana Kadifkova Panovska1
1Ss Cyril and Methodius University in Skopje, Faculty of Pharmacy, Institute of Applied Biochemistry, Mother Theresa 47, 1000 Skopje, Republic of North Macedonia
2Ss Cyril and Methodius University in Skopje, Faculty of Pharmacy, Institute of Pharmacognosy, Mother Theresa 47, 1000 Skopje, Republic of North Macedonia

Antioxidant and antimicrobial activity of Pleurotus ostreatus extracts
Jelena Radović Selgrad; Tatjana Kundaković-Vasović*
University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11000 Belgrade, Serbia

Influence of toxic metal mixture on acetylcholinesterase activity in subchronic exposure in rats
Đ. Marić, E. Antonijević Miljaković, J. Marić, D. Javorac, K. Baralić, D. Đukić-Ćosić, Z. Bulat, B. Antonijević, A. Buha Djordjevic
Department of Toxicology “Akademik Danilo Soldatović”, University of Belgrade – Faculty of Pharmacy, Serbia

Determination of gluten in various food products using ELISA method
Shenaj Skenderoska Adjija; Maja Dimitrovska*; Biljana Chuleva; Jasmina Jovanovska Veljanovska
Institute of Public Health, 50th Divizija 6, 1000 Skopje, Republic of North Macedonia

Chemical composition of the ethanol extracts ofVerbascum niveum flowers and leaves
Maja Grigorov1; Dragana Pavlović1; Vanja Tadić2; Ivana Nešić1; Bojan Zlatković3
1Department of Pharmacy, Faculty of Medicine, University of Niš, Dr Zoran Đinđić Boulevard 81, 18000 Niš, Serbia
2Department of Pharmaceutical Research and Development, Institute for Medicinal Plant Research “Dr Josif Pančić”, Tadeuša Košćuška 1, 11 000 Belgrade, Serbia
3Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Niš, Višegradska 33, 18000 Niš, Serbia

In silico prediction of physicochemical, pharmacokinetic and toxicological properties of sulforaphane
Katarina Živančević1,2*, Dragica Bozic1, Katarina Baralić1, Marijana Ćurčić1, Evica Antonijević Miljaković1, Biljana Antonijević1, Danijela Đukić-Ćosić1
1University of Belgrade – Faculty of Pharmacy, Department of Toxicology “Akademik Danilo Soldatović”, Vojvode Stepe 450, 11000 Belgrade, Serbia
2University of Belgrade – Faculty of Biology, Institute of Physiology and Biochemistry “Ivan Djaja”, Center for Laser Microscopy, Studentski trg 16, 11158, Belgrade, Serbia

Blood Pb and Cd levels – Human biomonitoring study in Serbia: DecodExpo project
Dragana Javorac1*, Katarina Baralić1, Đurđica Marić1, Danijela Đukić-Ćosić1, Stefan Mandić Rajčević2, Aleksandra Repić3, Vera Bonderović1, Vladimir Đorđević4, Miroslav Granić5, Miodrag Aćimović6, Aleksandra Buha Djordjevic1
1Department of Toxicology “Akademik Danilo Soldatović”, University of Belgrade – Faculty of Pharmacy, 11221 Belgrade, Serbia
2Institute of Social Medicine and School of Public Health and Health Management, Faculty of Medicine, University of Belgrade, Dr Subotića 15, 11000 Belgrade, Serbia
3Institute of Forensic Medicine, University of Belgrade– Faculty of Medicine, 31a Deligradska Street, 11000 Belgrade, Serbia o
4Clinic for Digestive Surgery, First Surgical Clinic, Clinical Centre of Serbia, 11000 Belgrade, Serbia
5University Hospital Medical Center Bezanijska Kosa, 11080, Belgrade, Serbia
6Clinical Center of Serbia, Urological Clinic, Belgrade, Serbia

Incidence of β-lactoglobulin intolerance among lactose intolerance suspected population and diagnostic approach
Boban Dobrevski1*, Tanja Petreska Ivanovska2, Zoran Zhivikj2, Olgica Sibinovska1,Olivija Efinska Mladenovska1, Teodora Brnjarchevska Blazevska1, Meri Kirijas1
1Ss. Cyril and Methodius University in Skopje, Faculty of Medicine, Institute of Immunobiology and Human Genetics, 50 Divizija 6, 1000 Skopje, Republic of North Macedonia
2Ss. Cyril and Methodius University of Skopje, Faculty of Pharmacy, Institute of Applied Biochemistry, Majka Tereza 47, 1000 Skopje, Republic of North Macedonia

Adiponectin/immunoglobulins combination for distinction of allergic inflammation from other immunodeficiency disorders
Milena Spasovska1*; Tatjana Kadifkova Panovska2
1Diagnostic clinical laboratory P.H.I. General Hospital, Sirma Vojvoda 1, 6000 Ohrid, R. N. Macedonia
2Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje, Mother Theresa 47, 1000 Skopje, R. N.  Macedonia

The potential anti-inflammatory role of adiponectin in developing allergic asthma
Milena Spasovska1*, Tatjana Kadifkova Panovska2
1Diagnostic clinical laboratory P.H.I. General Hospital, Sirma Vojvoda 1, 6000, Ohrid, Republic of North. Macedonia
2Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje, Mother Theresa 47, 1000, Skopje, Republic of North Macedonia

Content of Fe and other selected elements in Chenopodium album L. and Chenopodium botrysL. (Amaranthaceae) from Macedonian flora
Ljubica Adji Andov1,2*, Marija Karapandzova2, Ivana Cvetkovikj2*, Gjoshe Stefkov2, Katerina Baceva Andonovska3, Trajce Stafilov4, Svetlana Kulevanova2
1Diagnostic laboratory ‘Ramus‘, Naroden front 14, 1000 Skopje, R. N. Macedonia
2Institute of Pharmacognosy, Faculty of Pharmacy,Ss. Cyril and Methodius University in Skopje, Mother Theresa 47, 1000 Skopje, R. N. Macedonia
3Research Center for Environment and Materials, Macedonian Academy of Sciences and Arts, KrsteMisirkov 2, 1000 Skopje, R. N. Macedonia
4Institute of Chemistry, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University in Skopje, Arhimedova 5, POB 162, 1000 Skopje, R. N. Macedonia

Novel laboratory biomarkers in colorectal cancer management
Marija Gegovska, Marija Hiljadnikova-Bajro
Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje, Mother Theresa 47, 1000 Skopje, Republic of North Macedonia

Effects of toxic metal mixtures on hematologic parameters in male Wistar rats after the subchronic exposure
Katarina Baralić, ĐorđeStanivuk, Dragana Javorac, Đurđica Marić, Evica Antonijević Miljaković, Marijana Ćurčić, Danijela Đukić-Ćosić, Zorica Bulat, Aleksandra Buha Djordjevic
University of Belgrade – Faculty of Pharmacy, Department of Toxicology “Akademik Danilo Soldatović”, Vojvode Stepe 450, 11221 Belgrade, Serbia

Toxic potential of Pseudomonas aeruginosa mannose-sensitive hemagglutinin: in silico investigation of adverse outcomes in cancer patients
Dragica Bozic1, Katarina Živančević1,2, Katarina Baralić1, Dragana Javorac1, Đurđica Marić1, Aleksandra Buha Đorđević1, Zorica Bulat1, Danijela Đukić-Ćosić1
1University of Belgrade – Faculty of Pharmacy, Department of Toxicology “Akademik Danilo Soldatović”, Vojvode Stepe 450, 11000 Belgrade, Serbia
2University of Belgrade – Faculty of Biology, Institute of Physiology and Biochemistry “Ivan Djaja”, Center for Laser Microscopy, Studentski trg 16, 11158 Belgrade, Serbia

Toxicogenomics: opportunities and challenges of application in drug development, toxicity prediction and human health risk assessment
Danijela Đukić-Ćosić*
University of Belgrade – Faculty of Pharmacy, Department of Toxicology “Akademik Danilo Soldatović“, Vojvode Stepe 450, 11000 Belgrade, Serbia

Cytotoxic screening of selected Cannabis cultivars using brine shrimp lethality assay
Zoran Zhivikj1*, Kristina Shutevska1, Ana Marija Bajatovska1, Sevda Sofronievska1, Marija Karapandzova2, Ivana Cvetkovikj Karanfilova2, Iskra Davkova2, Lidija Petrushevska-Tozi1, Gjoshe Stefkov2, Tatjana Kadifkova Panovska1
1Ss Cyril and Methodius University in Skopje, Faculty of Pharmacy, Institute of Applied Biochemistry, Mother Theresa 47, 1000 Skopje, Republic of North Macedonia
2Ss Cyril and Methodius University in Skopje, Faculty of Pharmacy, Institute of Pharmacognosy, Mother Theresa 47, 1000 Skopje, Republic of North Macedonia

Estimation of the relationship between diazepam use and risk of violent death using post-mortem data
Marija Bujaroska1, Ioannis Papoutsis2, Liljana Anastasova3, Rumenka Petkovska3, Tanja Petreska Ivanovska3, Chara Spiliopoulou2, Aleksandar Stankov1, Lidija Petrushevska-Tozi3
1Institute of Forensic Medicine, Criminology and Medical Deontology, Medical Faculty, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia
2Department of Forensic Medicine and Toxicology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
3Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje, Republic of North Macedonia

Assessment of dietary supplement consumption in Republic of North Macedonia during the COVID 19 pandemic
Zoran Zhivikj1*, Ana Marija Bajatovska1, Tanja Petreska Ivanovska1, Marijana Lonchar Velkova2, Lidija Petrushevska-Tozi1
1University Ss Cyril and Methodius, Faculty of Pharmacy, Institute of Applied Biochemistry, Mother Theresa 47, 1000 Skopje, Republic of North Macedonia
2Consumer Organization of North Macedonia, 50 Division 10A, 1000, Skopje, Republic of North Macedonia

Nontoxicity and anti-inflammatory effect of extracts from Echinacea purpurea and Onopordum acanthium
Maria Vlasheva1*, Mariana Katsarova1, Petia Gardjeva3, Hristina Zlatanova2, Ilin Kandilarov2, Viktor Filipov4, Stela Dimitrova
1Faculty of Pharmacy, Medical university of Plovdiv, Department of Bioorganic chemistry, 15A V. Aprilov Blvd, 4000 Plovdiv, Bulgaria
2Faculty of Medicine, Medical university of Plovdiv, Department of Pharmacology and Clinical Pharmacology, 15A V.Aprilov Blvd, 4000 Plovdiv, Bulgaria
3Faculty of Pharmacy, Medical university of Plovdiv, Department of Microbiology and imunology, 15A V.Aprilov Blvd, 4000 Plovdiv, Bulgaria
4Faculty of Medicine, Medical university of Plovdiv, 15A V.Aprilov Blvd, 4000 Plovdiv, Bulgaria

SECTION: PHARMACEUTICAL CHEMISTRY/BIOMOLECULAR SCIENCES

Optimization of enzymatic desialylation of human serum transferrin
Tomislav Friganović*, Valentina Borko, Tin Weitner
Faculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovačića 1, 10000 Zagreb, Croatia

The role of probiotics in the vaginal microbiome
Kornelija Trajkova1,2,*, Biljana Curcic3, Aleksandar Dimovski4,5, Katerina Kubelka Sabit2,6, Katerina Popovska Jankovic5, Dimitar Trajkov7, Gordana Adamova8, Milena Petrovska9
1Department of Gynecology and Obstetrics. Clinical Hospital “Acibadem Sistina”, 1000 Skopje, R. North Macedonia
2Faculty of Medical Sciences. University “Goce Delcev”, Stip, Republic of North Macedonia
3Diagnostic Laboratories/Microbiology and Parasitology, Clinical Hospital “Acibadem Sistina”, 1000 Skopje, R. North Macedonia
4Research Center for Genetic Engineering and Biotechnology “Georgi D. Efremov“. Macedonian Academy of Sciences and Art – MASA, 1000 Skopje, R. North Macedonia
5Faculty of Pharmacy, University “Ss. Cyril and Methodius”, 1000 Skopje, R. North Macedonia
6Diagnostic Laboratories/Deaprtment of Clinical PathologY, Clinical Hospital “Acibadem Sistina”, 1000 Skopje, R. North Macedonia
7Department of Gatroenterohepathology, Clinical Hospital “Acibadem Sistina”, 1000 Skopje, R. North Macedonia
8Obstetrics and Gynecology. Medical Faculty, University “Ss. Cyril and Methodius”, 1000 Skopje, R.North Macedonia
9Microbiology and Parasitology, Medical Faculty, University “Ss. Cyril and Methodius”, 1000 Skopje, R.North Macedonia

Mitochondrial DNA mutations are not a common cause of non-syndromic hearing loss in Republic of Macedonia
Emilija Shukarova Stefanovska1, Marina Davceva Chakar2, Gjorgji Bozhinovski1
1Research Center for Genetic Engineering and Biotechnology “Georgi D. Efremov“, Macedonian Academy of Sciences and Arts, 1000 Skopje, R.N. Macedonia
2Othorinolaryngology Clinic, Medical Faculty, 1000 Skopje, R.N. Macedonia

A series of 2-pyrazolines endowed with potent anticandidal activity
Mehlika Dilek Altintop1*, Zerrin Cantürk2, Ahmet Özdemir1
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey
2Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey

Design and synthetic approach of novel hybrid molecules for treatment of Alzheimer’s disease
Aleksandar Dimkovski, Evgenija Mihajloska, Olga Gigopulu, Zorica Naumovska, Ljubica Suturkova, Ana Poceva Panovska
University Ss Cyril and Methodius, Faculty of Pharmacy, Mother Theresa 47, 1000 Skopje, Republic of North Macedonia

Effect of the sialic acid residues upon the binding of beta blocker propranolol to human serum alpha-1 acid glycoprotein
Robert Kerep*, Tino Šeba, Mario Gabričević
University of Zagreb, Faculty of Pharmacy and Biochemistry, A. Kovačić 1, Zagreb, Croatia

Fluorescence polarization binding characterization of dipyridamole and imatinib on alpha-1-acid glycoprotein
Tino Šeba*, Robert Kerep, Mario Gabričević
University of Zagreb, Faculty of Pharmacy and Biochemistry, A. Kovačića 1, HR-10000 Zagreb, Croatia

Antiplasmodial activity of harmirins – novel harmine–coumarin hybrids
Kristina Pavić1*, Zrinka Rajić1, Lais Pessanha de Carvalho2, Jana Held2,3
1University of Zagreb, Faculty of Pharmacy and Biochemistry, A. Kovačića 1, HR-10000 Zagreb, Croatia
2University of Tübingen, Institute of Tropical Medicine, Wilhelmstraße 27, 72074, Tübingen, Germany
3German Center for Infection Research (DZIF), Partner Site Tübingen, 72074, Tübingen, Germany

SECTION: COMMUNITY/HOSPITAL PHARMACY

Knowledge, opinions and attitudes of the general population in the Republic of N. Macedonia about vaccines and vaccination
Meri Stojanovska1, Zorica Naumovska2, Aleksandra Kapedanovska Nestorovska2, Aleksandra Grozdanova2, Maja Simonoska Crcarevska1
1Institute of Pharmaceutical Technology, Faculty of Pharmacy, University “Ss. Cyril and Methoduis”, Majka Tereza 47, 1000 Skopje, Republic of N. Macedonia
2Institute of Pharmaceutical Chemistry, Faculty of Pharmacy, University “Ss. Cyril and Methoduis”, Majka Tereza 47, 1000 Skopje, Republic of N. Macedonia

Drug interactions – a cross-section of the situation at the primary level of healthcare in Montenegro
Ninoslava Lalatovic1, Snezana Pantovic1, Masa Marojevic2
1University of Montenegro, Faculty of Medicine, Krusevac bb 81000 Podgorica, Montenegro
2Special Hospital for Orthopedics, Neurosurgery and Neurology “Vaso Ćuković”, Risan, Montenegro

Legal framework and regulatory requirements for community pharmacies in some Balkan countries
Radiana Staynova1*, Nelina Hadzhieva2*, Shazie Hasanova2, Maria Bacheva2, Violeta Getova3
1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University of Plovdiv, 15A Vassil Aprilov Blvd, 4002 Plovdiv, Bulgaria
2Faculty of Pharmacy, Medical University of Plovdiv, 15A Vassil Aprilov Blvd, 4002 Plovdiv, Bulgaria
3Faculty of Pharmacy, Medical University-Sofia, 1000 Sofia, Bulgaria

Pharmacists` vaccine basic knowledge and attitudes in the RN Macedonia
Sanda Krmova1,2 *, Aleksandra Kapedanovska Nestorovska2, Maja Simonoska Crcarevska2, Aleksandra Grozdanova2, Zorica Naumovska2
1Zegin, Bel Kamen 6, 1000 Skopje, RN Macedonia
2Faculty of Pharmacy, Ss. Cyril and Methodius University, Majka Tereza 47, 1000 Skopje, RN Macedonia

Study on current therapeutic management of breast cancer in hospital and university clinical service of Kosovo
Valon Ejupi1, Leonora Demiri2, Bujar Qazimi1, Shpend Dragusha1
1Faculty of Pharmacy, UBT College – Higher Education Institution, Lagjia Kalabria, 10000 Pristina, R. of Kosovo
2Faculty of Nursing, UBT College – Higher Education Institution, Lagjia Kalabria, 10000 Pristina, R. of Kosovo

Antibiotic usage in Pediatric ward in Ferizaj Hospital
Shpend Dragusha1, Habibe Gjinolli2, Bujar Qazimi1, Valon Ejupi1
1UBT-Higher Education Institution, Faculty of Pharmacy, Lagjja Kalabria, p.n. 10000 Prishtinë, Kosovo
2UBT-Higher Education Institution, Faculty of Nursing, Lagjja Kalabria, p.n. 10000 Prishtinë, Kosovo

SECTION: PHARMACOECONOMY/DRUG INFORMATION

Risk management strategies and implementation of risk minimization measures for medicinal products |
Marija Guleva1*, Zorica Naumovska2, Aleksandra K. Nestorovska2, Angela Mircheska-Janevska3, Ankica Gestakovska1
1Farma Trejd DOOEL, Anton Popov street No. 1/1-3, 1000 Skopje, N. Macedonia
2Faculty of Pharmacy, Ss. Cyril and Methodius University, Mother Theresa 47, 1000 Skopje, N. Macedonia
3Ino-Medix DOOEL, Slave Delovski street No. 7, 1000 Skopje, N. Macedonia

Safety of Covid-19 vaccines: one year post-marketing analysis
Denitsa Panayotova, Antonio Ivanov, Ines Hababa, Maria Dimitrova, Ilko Getov
Medical University Sofia, Faculty of Pharmacy, 2 Dunav str., 1000 Sofia, Bulgaria

Legal framework for pharmacovigilance inspection
Slavica Onceska1*, Aleksandra Kapedanovska Nestorovska2, Zoran Sterjev2, Zorica Naumovska2
1Agency for drugs and medical devices, Blvd. Ss. Cyril and Methodius 54, 1000 Skopje, R.N. Macedonia
2Faculty of Pharmacy, Ss. Cyril and Methodius University, Majka Tereza 47, 1000 Skopje, RN Macedonia

Consumption of antibiotics on burden of Health Insurance Fund of North Macedonia
Kristina Hristova, Blerina Tushi, Sonja Zlatanovska
HIFRNM, Ul. Makedonija br. 5, Skopje North Macedonia

Consumption trends of the new generation of antidiabetics from the Essential List of Sarajevo Canton
Vedina Cordalija 1, Nermina Ziga Smajic 2, Edisa Trumic 3, Tea Music 4, Fahir Becic2
1Public Institution Psychiatric hospital, Nahorevska 248, 71 000 Sarajevo, Bosnia and Herzegovina
2University in Sarajevo, Faculty of Pharmacy, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina
3University in Tuzla, Faculty of Pharmacy, Univerzitetska 8, 75 000 Tuzla, Bosnia and Herzegovina
4Mobis Pharm, Bišće polje bb, 88 000Mostar, Bosnia and Herzegovina

Pharmacoeconomic analysis of parenteral therapy consumption in hospital pharmacy at Clinical Hospital – Stip
Tamara Tashkov 1*,  Biljana Lazarova1, Lidija Mihailova1, Elena Drakalska2, Bistra Angelovska2
1Clinical hospital Stip, Ljuben Ivanov BB, 2000 Stip, Republic of N. Macedonia
2Faculty of medical Science,s Goce Delcev University, Krste Misirkov BB, 2000 Stip, Republic of N. Macedonia

New pharmacotherapeutic aspects associated with the use of metformin
Iskra Tanushevska, Aleksandra Grozdanova, Aleksandra Kapedanovska Nestorovska, Zorica Naumovska, Zoran Sterjev
University Ss Cyril and Methodius, Faculty of Pharmacy, Mother Theresa 47, 1000 Skopje, Republic of North Macedonia 

Antidepressant and anxiolytic consumption during COVID-19 pandemic
Dragana Dimkovikj1, Olga Gigopulu2 Zorica Naumovska3, Zoran Sterjev3.
1Pharmacy Adonis-Farm, III MUB 5/4, 1300 Kumanovo, North Macedonia Faculty of pharmacy
2Institute so Applied Chemistry and Pharmaceutical Analysis, Faculty of Pharmacy, University “Ss. Cyril and Methoduis”, Majka Tereza 47, 1000 Skopje, Republic of N. Macedonia
3Institute of Pharmaceutical chemistry, Faculty of Pharmacy, University “Ss. Cyril and Methoduis”, Majka Tereza 47, 1000 Skopje, Republic of N. Macedonia

Activities of the National Center for Drug Information during COVID-19 pandemic
Evgenija Mihajloska*, Aleksandar Dimkovski, Damjan Georgievski, Mateja Stojceva, Emilija Mitrevska, Angela Simovska, Aleksandra Kapedanovska Nestorovska, Zorica Naumovska
Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje, str. Mother Tereza 47, 1000 Skopje, R.N. Macedonia

Analysis of the drugs consumption for hyperthyroidism in Republic of North Macedonia for the period of 2016-2019
Bistra Angelovska, Elena Drakalska Sersemova, Dijana Miceva
Faculty of Medical Sciences, Goce Delcev University, Krste Misirkov bb, 2000 Shtip, Republic of North Macedonia

Analysis of hyaluronic acid usage in Municipality of Stip
Dijana Miceva1*, Elena Drakalska Sersemova1, Tamara Tashkov2, Bistra Angelovska1
1Faculty of Medical Sciences, Goce Delcev University, Krste Misirkov bb, 2000 Shtip, Republic of North Macedonia
2Clinical Hospital-Shtip, Ljuben Ivanov 25, 2000 Stip, N. Macedonia

Use of medicines in Bosnia and Herzegovina
Tea Mušić1, Belma Tuna-Repovac2, Katica Velija3, Vedina Čordalija4
1Mobis pharm, Clinical pharmacist, Jovana Bijelića 8, 71000 Sarajevo BIH
2Privacy pharmacy Monis, Bulevar Franca Lehara 2, 71000 Sarajevo BIH
3Faculty of Veterinary Medicine, Dzemala Bijedića bb, 71000 Sarajevo BIH
4Psihiatric hospital, Clinical pharmacist, Panjina kula 73, 71000 Sarajevo BIH

SECTION: SOCIAL PHARMACY/PHARMACEUTICAL LAW

Percentage of disease incidence and different experiencesin the treatment of Covid-19 infection in the student population
Isidora Milanović*, Jasmina Bašić, Danijela Pecarski, Dragana Dragaš Milovanović
Academy of Applied Studies Belgrade, College of Health Science, Cara Dušana, Zemun, Serbia

Impact of intellectual property rights on the access to COVID-19 vaccines
Aleksandar Dimkovski, Evgenija Mihajloska, Aleksandra Grozdanova, Ljubica Suturkova, Katerina Ancevska Netkovska
Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje, str. Mother Tereza 47, 1000 Skopje, R.N. Macedonia

Global Marketing Authorization: A field of frequent legal disputes and its benefits to generic companies
Dijana Nechkova1*, Damjan Bekjarovski1, Aleksandra Krstevska1, Marija Mitkovska1 Katerina Anchevska Netkovska2
1Alkaloid AD Skopje, Blvd. Aleksandar Makedonski 12, 1000 Skopje, North Macedonia
2Faculty of Pharmacy, Ss. Cyril and Methodius University, 1000 Skopje, Republic of North Macedonia

Medical use patents of antineoplastics: new trend of ‘evergreening’ and prevention generics on the market
Emilija Koneska1*, Marija Mitkovska1, Katerina Anchevska Netkovska2.
1Alkaloid AD Skopje, Blvd. Aleksandar Makedonski 12, 1000 Skopje, North Macedonia
2Faculty of Pharmacy, Ss. Cyril and Methodius University, Mother Teresa 47, 1000 Skopje, North Macedonia

Requirements and possibilities for reporting ADRs: a comparative analysis between Bulgaria and the Republic of North Macedonia
Violeta Getova1, Radiana Staynova2, Hristina Lebanova3, Svetoslav Stoev3, Ilko Getov1
1Faculty of Pharmacy, Medical University-Sofia, 1000 Sofia, Bulgaria
2Department of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria
3Faculty of pharmacy, Medical University-Pleven, 5800 Pleven, Bulgaria

SECTION: CLINICAL PHARMACY

Improving the safety of prescribing and using antibiotics in the treatment of exacerbations of COPD in hospitalized patients in tertiary care
Olivera K. Nakovska1, Dejan Dokic1, Dimitar Karkinski1, Vangel Nechevski1, Elena Janeva1, Milena M. Gjorevska1, Angela Debreslioska1, Ksenija Bogoeva2, Zorica Naumovska3, Aleksandra K. Nestorovska3, Ljubica Suturkova3
1University Clinic of Pulmonology and Allergology, Majka Tereza 17, 1000 Skopje, Republic of North Macedonia
2PZU Bogoeva, Frederik Chopin 2/1, 1000 Skopje, Republic of North Macedonia
3Faculty of Pharmacy, University “Ss Cyril and Methodius”, Mother Theresa 45, 1000 Skopje, Republic of North Macedonia

Potential drug-drug interactions found in therapeutic treatment during COVID-19
Dhurata Bytyçi1, Yllka Bytyçi1, Nderim Kryeziu2, Aleksandra Kapedanovska-Nestorovska3, Zorica Naumovska3
1Community Pharmacy ‘’Tea’’, 12 Qershori, 70000 Ferizaj, Kosova
2Alma Mater Europaea Campus College “Rezonanca”, Glloku te Shelgjet “Veternik”, 10000 Prishtina, Kosovo
3Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy, Majka Tereza 47, 1000 Skopje, North Macedonia

Constitution, storage and delivery of risdiplam is easy to manage by the hospital pharmacist – single case study
Branka Pasaliska Cvetkov*, Ivan Barbov, Jasmina Korunoska
PHI University clinic of neurology – Skopje, Mother Teresa No. 7, 1000 Skopje, North Macedonia

SECTION: STUDENT SESSION

The effect of different formulations with colloidal oatmeal on the epidermal barrier function and hydration
Jehona Bela1*, Teodora Dodov2, Maja Simonoska Crcarevska1, Marija Glavas Dodov1
1Center of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Ss Cyril and Methodius University in Skopje, Mother Teresa 47, 1000 Skopje, R.N. Macedonia
2Faculty of Medicine, Ss Cyril and Methodius University in Skopje, 50 Divizija 6, 1000 Skopje, R.N. Macedonia

Post-pandemic period in N. Macedonia: an opportunity to expand the role of pharmacist
Iskra Jordanovska*, Katerina Anchevska Netkovska, Aleksandra Kapedanovska Nestorovska, Aleksandra Grozdanova
Faculty of Pharmacy, University of Ss. Cyril and Methodius, Mother Theresa 47, 1000 Skopje, N. Macedonia 

Use of tocilizumab for treatment of COVID-19 from off-label to extended indication
Iskra Velevska1, Jovana Aleksov1, Evgenija Mihajloska1, Aleksandar Dimkovski1, Irina Panovska-Stavridis2, Milena Stevanovic3, Aleksandra Grozdanova*1
1Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje, Mother Tereza 47, 1000 Skopje, R.N.  Macedonia
2University Clinic of Hematology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Mother Tereza 47, 1000 Skopje, R.N. Macedonia
3University Clinic of Infection Diseases and Febrile Conditions, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Mother Tereza 47, 1000 Skopje, R.N. Macedonia

Preparation of Oxaliplatin loaded PLGA-Glucose nanoparticles by nanoprecipitation and emulsification/solvent evaporation techniques
Teodora Mazneva*, Dushko Shalabalija, Ljubica Mihailova, Nikola Geskovski, Katerina Goracinov
Institute of Pharmaceutical technology, Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje, Majka Tereza 47, 1000 Skopje, Republic of North Macedonia

Revealing wild Cannabis at the territory of North Macedonia
Jovana Gjorgjievska*, Dimitar Stefkov, Veronika Stoilkovska Gjorgievska, Ivana Cvetkovikj Karanfilova, Ana Trajkovska, Marija Karapandzova, Svetlana Kulevanova, Gjose Stefkov
Institute of Pharmacognosy, Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje, Mother Theresa 47, 1000 Skopje, Republic of North Macedonia

Comparison of terpenе profile in fresh and dry flowers of cultivated commercial strains and wildtype of Cannabis
Martina Samarakova, Ana Stoilkovska, Veronika Stoilkovska Gjorgievska*, Ivana Cvetkovikj Karanfilova, Ana Trajkovska, Marija Karapandzova, Svetlana Kulevanova, Gjoshe Stefkov
Institute of pharmacognosy, Faculty of Pharmacy, Ss. Cyril and Methodius in Skpje University, Mother Theresa 47, 1000 Skopje, Republic of North Macedonia

Headspace GC/MS analysis of volatile terpenoids in native Helichrysum plicatum and Helichrysum zivojinii from Macedonian flora
Filip Todorov*, Laze Ramanchev, Ivana Cvetkovikj Karanfilova, Ana Trajkovska, Gjose Stefkov, Svetlana Kulevanova, Marija Karapandzova
Institute of Pharmacognosy, Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje, Majka Tereza 47, 1000 Skopje, Republic of North Macedonia

Evaluation of the antioxidant capacity of four Cannabis cultivars
Nadica Trajkovska1*, Iskra Davkova1, Ivana Cvetkovik Karanfilova1, Gjoshe Stefkov1, Veronika Stoilkovska Gorgievska1, Tanja Petrevska Ivanovska2, Svetlana Kulevanova1, Marija Karapandzova1
1Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy, Institute of Pharmacognosy, Mother Theresa 47, 1000 Skopje, Republic of North Macedonia
2Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy, Institute of Applied Biochemistry, Mother Theresa 47, 1000 Skopje, Republic of North Macedonia

Evaluation of the phenolic content and antioxidant capacity of Tanaceti herba from two locations from North Macedonia
Ivana Kochoska1*; Marko Naneski1, Marija Karapandzova1, Ana Trajkovska1, Zoran Zivikj2, Svetlana Kulevanova1, Gjoshe Stefkov1, Ivana Cvetkovikj Karanfilova1
1Institute of Pharmacognosy, Faculty of Pharmacy – Skopje, Ss. Cyril and Methodius University, Majka Tereza 47, 1000 Skopje, North Macedonia
2Institute of Applied Biochemistry, Faculty of Pharmacy – Skopje, Ss. Cyril and Methodius University, Majka Tereza 47, 1000 Skopje, North Macedonia

Biochemical markers for diagnosing and monitoring of acute pancreatitis
Anel Lila*, Marija Hiljadnikova Bajro
Ss Cyril and Methodius University in Skopje, Faculty of Pharmacy, Mother Theresa 47, 1000 Skopje, R.N. Macedonia

Current and future perspectives in laboratory analysis of Pituitary neuroendocrine tumors
Teodora Jovanova, Ivana Vichentijevikj, Debora Petrevska, Elena Ilievska, Marija H. Bajro
Faculty of Pharmacy, Ss Cyril and Methodius University in Skopje, Majka Tereza 47, 1000 Skopje, Republic of North Macedonia

Cross-contamination in pharmaceutical industry: types, measures and good practices
Kosara Lutovska*, Marija Glavas Dodov
Institute of Pharmaceutical technology, Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje, Mother Tereza 47, 1000 Skopje, North Macedonia